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1

Potential long acting opiate antagonists: Preparation, pharmacological activity and opiate-receptor binding of N-substituted 2′-hydroxy-5-methyl-9α-propyl-6,7-benzomorphans

Kenner C. Rice, Werner A. Klee, Mario D. Aceto, Henry H. Swain, Arthur E. Jacobson

Journal:

Journal of Pharmaceutical Sciences

Year:

1977

Language:

english

File:

PDF, 547 KB

english, 1977

2

The synthesis of methionine by enzymic transmethylation: VII. Existence of two separate homocysteine methylpherases on mammalian liver

Werner A. Klee, Henry H. Richards, G.L. Cantoni

Journal:

Biochimica et Biophysica Acta

Year:

1961

Language:

english

File:

PDF, 496 KB

english, 1961

3

Synthesis of leucine enkephalin derivatives: Structure-function studies

Nirankar S. Agarwal, Victor J. Hruby, Robert Katz, Werner Klee, Marshall Nirenberg

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 409 KB

english, 1977

4

Additions and Corrections - Paradoxical Effects of N-Cyano-alkyl Substituents upon the Activities of Several Classes of Opioids

Jacobson, Arthur, Rice, Kenner, Reden, Jurgen, Lupinacci, Lillian, Brossi, Arnold, Streaty, Richard, Klee, Werner

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 106 KB

english, 1979

5

Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids

Jacobson, Arthur E., Rice, Kenner C., Reden, Juergen, Lupinacci, Lillian, Brossi, Arnold, Streaty, Richard A., Klee, Werner A.

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 516 KB

english, 1979

6

Probes for narcotic receptor mediated phenomena 8. Tritiation of irreversible mu or delta specific opioid receptor affinity ligands to high specific activity

Terrence R. Burke Jr., Kenner C. Rice, Arthur E. Jacobson, William F. Simonds, Werner A. Klee

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1984

Language:

english

File:

PDF, 381 KB

english, 1984

7

α- and β-halomorphides: Stereochemistry, analgesic potency, toxicity, and interaction with narcotic receptors in vitro

Herman J. C. Yeh, Raymond S. Wilson, Werner A. Klee, Arthur E. Jacobson

Journal:

Journal of Pharmaceutical Sciences

Year:

1976

Language:

english

File:

PDF, 330 KB

english, 1976

8

A new class of nonionic detergents with a gluconamide polar group

Leonard M. Hjelmeland, Werner A. Klee, James C. Osborne Jr.

Journal:

Analytical Biochemistry

Year:

1983

Language:

english

File:

PDF, 512 KB

english, 1983

9

Narcotic Receptor Sites in Morphine-dependent Rats

KLEE, WERNER A., STREATY, RICHARD A.

Journal:

Year:

1974

File:

PDF, 323 KB

1974

10

Mode of action of endogenous opiate peptides

KLEE, WERNER A., NIRENBERG, MARSHALL

Journal:

Year:

1976

File:

PDF, 462 KB

1976

11

Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma × glioma hybrid cells

GOLDSTEIN, AVRAM, COX, BRIAN M., KLEE, WERNER A., NIRENBERG, MARSHALL

Journal:

Year:

1977

File:

PDF, 229 KB

1977

12

The synthesis of methionine by enzymic transmethylation: V. Chromatographic analysis of thetin-homocysteine methylpherase on modified cellulose columns

Journal:

Biochimica et Biophysica Acta

Year:

1960

Language:

english

File:

PDF, 535 KB

english, 1960

13

The synthesis of methionine by enzymic transmethylation: VI. Studies of the homogeneity, shape properties and monomer functionality of thetin-homocysteine methylpherase

Werner A. Klee, G.L. Cantoni

Journal:

Biochimica et Biophysica Acta

Year:

1960

Language:

english

File:

PDF, 717 KB

english, 1960

14

The synthesis of methionine by enzymic transmethylation: IX. Formation of subunits of thetin-homocysteine methylpherase by reaction with sodium dodecyl sulfate

Journal:

Biochimica et Biophysica Acta

Year:

1962

Language:

english

File:

PDF, 365 KB

english, 1962

15

Identification of a Mr 58 000 glycoprotein subunit of the opiate receptor

Werner A. Klee, William F. Simonds, Floyd W. Sweat, Terrence R. Burke jr, Arthur E. Jacobson, Kenner C. Rice

Journal:

Year:

1982

Language:

english

File:

PDF, 446 KB

english, 1982

16

The GTP-binding regulatory proteins of neuroblastoma × glioma, NG108-15, and glioma, C6, cells: Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No

Graeme Milligan, Peter Gierschik, Allen M. Spiegel, Werner A. Klee

Journal:

Year:

1986

Language:

english

File:

PDF, 812 KB

english, 1986

17

Guanine nucleotide dependent and independent reconstitution of G-proteins with adenylate cyclase: stimulation or attenuation of the enzyme by Gi α subunits

Dianne L. Newton, Werner A. Klee

Journal:

Year:

1990

Language:

english

File:

PDF, 474 KB

english, 1990

18

Developmental expression of G proteins that differentially modulate adenylyl cyclase activity in mouse brain

R.Adrian Rius, Richard A. Streaty, Y.Peng Loh, Werner A. Klee

Journal:

Year:

1991

Language:

english

File:

PDF, 415 KB

english, 1991

19

Agonist regulation of the expression of the delta opioid receptor in NG108-15 cells

Dong Sun Kim, Hemin Chin, Werner A. Klee

Journal:

Year:

1995

Language:

english

File:

PDF, 340 KB

english, 1995

20

Opioid activities and structures of .alpha.-casein-derived exorphins

Loukas, Spyros, Varoucha, Dido, Zioudrou, Christine, Streaty, Richard A., Klee, Werner A.

Journal:

Year:

1983

Language:

english

File:

PDF, 1.79 MB

english, 1983

21

The role of α-lactalbumin in lactose synthetase

Werner A. Klee, Claude B. Klee

Journal:

Biochemical and Biophysical Research Communications

Year:

1970

Language:

english

File:

PDF, 384 KB

english, 1970

22

β-endrophin: modulation of acute tolerance and antagonism by endogenous brain systems

Yasuko F. Jacquet, Werner A. Klee, Derek G. Smyth

Journal:

Year:

1978

Language:

english

File:

PDF, 386 KB

english, 1978

23

Antagonist potency and receptor binding

Florin Ionescu, Werner Klee, Robert Katz

Journal:

Year:

1975

Language:

english

File:

PDF, 81 KB

english, 1975

24

Opiate receptors as regulators of adenylate cyclase

Werner A. Klee, Shail K. Sharma, Marshall Nirenberg

Journal:

Year:

1975

Language:

english

File:

PDF, 316 KB

english, 1975

25

Effect of dehydration on the endogenous opiate content of the art neuro-intermediate lobe

Marina M. Mata, Harold Gainer, Werner A. Klee

Journal:

Year:

1977

Language:

english

File:

PDF, 224 KB

english, 1977

26

Probes for narcotic receptor mediated phenomena. 5. Narcotic antagonist irreversible ligands based on endoethenotetrahydrooripavine

Arthur E. Jacobson, Balbir S. Bajwa, Richard A. Streaty, Werner A. Klee, Kenner C. Rice

Journal:

Year:

1983

Language:

english

File:

PDF, 223 KB

english, 1983

27

Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for .delta. opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity

Burke, Terrence R., Jacobson, Arthur E., Rice, Kenner C., Silverton, J. V., Simonds, William F., Streaty, Richard A., Klee, Werner A.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 928 KB

english, 1986

28

Magnetic microemulsions based on magnetic ionic liquids

Klee, Andreas, Prevost, Sylvain, Kunz, Werner, Schweins, Ralf, Kiefer, Klaus, Gradzielski, Michael

Journal:

Physical Chemistry Chemical Physics

Year:

2012

Language:

english

File:

PDF, 1.77 MB

english, 2012

29

The Conformation of Ribonucleosides in Solution. The Effect of Structure on the Orientation of the Base *

Klee, Werner A., Mudd, S. Harvey

Journal:

Year:

1967

Language:

english

File:

PDF, 1009 KB

english, 1967

30

Analgetic activity and in vitro binding constants of some N-alkyl-3-benzazocines

Rogers, Michael E., Ong, Helen H., May, Everette L., Klee, Werner A.

Journal:

Journal of Medicinal Chemistry

Year:

1975

Language:

english

File:

PDF, 360 KB

english, 1975

31

Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone

Iijima, Ikuo, Minamikawa, Junichi, Jacobson, Arthur E., Brossi, Arnold, Rice, Kenner C., Klee, Werner A.

Journal:

Journal of Medicinal Chemistry

Year:

1978

Language:

english

File:

PDF, 381 KB

english, 1978

32

[Part 2: Biological Sciences] || Opiates Inhibit Adenylate Cyclase by Stimulating GTP Hydrolysis

Greg Koski and Werner A. Klee

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 950 KB

english, 1981

33

Purification of the Opiate Receptor of NG108-15 Neuroblastoma--Glioma Hybrid Cells

William F. Simonds, Terrence R. Burke, Kenner C. Rice, Arthur E. Jacobson and Werner A. Klee

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.21 MB

english, 1985

34

Antibodies against the Carboxyl-Terminal 5-kDa Peptide of the α Subunit of Transducin Crossreact with the 40-kDa but not the 39-kDa Guanine Nucleotide Binding Protein from Brain

Mark Pines, Peter Gierschik, Graeme Milligan, Werner Klee and Allen Spiegel

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.39 MB

english, 1985

35

Bradykinin-Activated Transmembrane Signals are Coupled Via Noor Nito Production of Inositol 1,4,5-trisphosphate, a Second Messenger in NG108-15 Neuroblastoma-Glioma Hybrid Cells

Haruhiro Higashida, Richard A. Streaty, Werner Klee and Marshall Nirenberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 915 KB

english, 1986

36

Use of Specific Antibodies to Quantitate the Guanine Nucleotide-Binding Protein Goin Brain

Peter Gierschik, Graeme Milligan, Mark Pines, Paul Goldsmith, Juan Codina, Werner Klee and Allen Spiegel

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 909 KB

english, 1986

37

A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors

Werner A. Klee and Marshall Nirenberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1974

Language:

english

File:

PDF, 632 KB

english, 1974

38

Morphine Receptors as Regulators of Adenylate Cyclase Activity

Shail K. Sharma, Marshall Nirenberg and Werner A. Klee

Journal:

Proceedings of the National Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 803 KB

english, 1975

39

Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance

Shail K. Sharma, Werner A. Klee and Marshall Nirenberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 1.06 MB

english, 1975

40

Tolerance and Dependence Evoked by an Endogenous Opiate Peptide

Arthur Lampert, Marshall Nirenberg and Werner A. Klee

Journal:

Proceedings of the National Academy of Sciences

Year:

1976

Language:

english

File:

PDF, 545 KB

english, 1976

41

Opiate-Dependent Modulation of Adenylate Cyclase

Shail K. Sharma, Werner A. Klee and Marshall Nirenberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 1.38 MB

english, 1977

42

Studies on Soluble Ribonucleic Acid (S-RNA) of Rabbit Liver, I. Amino Acid Acceptor Specificity and Molecular Weight

Werner A. Klee and G. L. Cantoni

Journal:

Proceedings of the National Academy of Sciences

Year:

1960

Language:

english

File:

PDF, 138 KB

english, 1960

43

[Part 2: Biological Sciences] || Solubilization of Active Opiate Receptors

William F. Simonds, Greg Koski, Richard A. Streaty, Leonard M. Hjelmeland and Werner A. Klee

Journal:

Proceedings of the National Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 815 KB

english, 1980

44

N-(2,4,5-Trihydroxyphenethyl)normetazocine, a potential irreversible inhibitor of the narcotic receptor

Rice, Kenner C., Shiotani, Shunsaku, Creveling, Cyrus R., Jacobson, Arthur E., Klee, Werner A.

Journal:

Journal of Medicinal Chemistry

Year:

1977

Language:

english

File:

PDF, 408 KB

english, 1977

45

Conformational studies of a series of overlapping peptides from ribonuclease and their relation to the protein structure

Brown, James Edward, Klee, Werner A.

Journal:

Year:

1969

Language:

english

File:

PDF, 410 KB

english, 1969

46

Comparison of (-)-eseroline with (+)-eseroline and dihydroseco analogs in antinociceptive assays: confirmation of rubreserine structure by x-ray analysis

Schonenberger, Bernhard, Jacobson, Arthur E., Brossi, Arnold, Streaty, Richard, Klee, Werner A., Flippen-Anderson, Judith L., Gilardi, Richard

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 773 KB

english, 1986

47

Intermediate Stages in the Thermally Induced Transconformation Reactions of Bovine Pancreatic Ribonuclease A *

Klee, Werner A.

Journal:

Year:

1967

Language:

english

File:

PDF, 607 KB

english, 1967

48

Conformation of ribonuclease S-peptide

Klee, Werner A.

Journal:

Year:

1968

Language:

english

File:

PDF, 603 KB

english, 1968

49

Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions

Reden, Juergen, Reich, Marvin F., Rice, Kenner C., Jacobson, Arthur E., Brossi, Arnold, Streaty, Richard A., Klee, Werner A.

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 589 KB

english, 1979

50

Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for the .delta.-opioid receptors in vitro

Kim, Chong Ho, Rothman, Richard B., Jacobson, Arthur E., Mattson, Mariena V., Bykov, Victor, Streaty, Richard A., Klee, Werner A., George, Clifford, Long, Joseph B., Rice, Kenner C.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 945 KB

english, 1989